Abstract: Advances in the Research on the Anti-cancer Effect of Pigment Epithelium-derived FactorWeixiang QI, Yang YAO, Zan SHENCorrespondence to: Yang YAO, E-mail: qiweixiang1113@163.comDepartment of Oncology, The Sixth People's Hospital, Medical College of Shanghai Jiaotong University, Shanghai 200233, ChinaAbstract Pigment epithelium-derived factor ( PEDF ) is a secreted glycoprotein with a molecular weight of 50 kDa, which has avariety of biological activities such as neurotrophic effect, neuroprotective effect, inhibiting tumor growth, promoting cell differentia-tion, and inhibiting angiogenesis. As a potential new anti-cancer drug, PEDF has been confirmed effective for different types of tumorcells in vitro and in vivo. This review focuses on the structure and function of PEDF, the mechanism of its anti-cancer effect and relatedexperimental studies.Keywords Pigment epithelium-derived factor; Cancer treatment; Serine protein kinase inhibitor